Antibody Discovery

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Antibody Discovery

Our technologies offer the ability to mine large antibody repertoires to generate target specific antibodies with desired functionalities and biophysical properties.

From candidate selection to lead characterization and developability assessment

Our team has deeply rooted expertise in antibody discovery, with established and cutting-edge technologies to rapidly identify high-quality antibodies tailored to your desired specifications. By mining large immune and non-immune antibody repertoires using phage display and/or our proprietary Mammalian Display, we generate target-specific antibodies for different applications.

This gold standard approach has resulted in at least 14 antibodies that have entered the clinic for our partners over the brief span of 10 years.

We pride ourselves on our total dedication to our partners. With consistent and transparent communication, we aim to deliver results that meet and often exceed expectations. Your vision becomes our mission, your goals become our objectives. Our commitment to excellence ensures we provide services that are not only efficient but also effective.

Vast Expertise in Antibody Discovery

In vitro and in vivo sources

Antibodies generated from a wide spectrum of both in vitro and in vivo sources, enabling a broad range of possibilities

Non-immune libraries

Fully human clinically validated proprietary non-immune libraries (naïve and semi-synthetic) ensuring a reliable basis for antibody discovery

Multiple Species

We support immunizations in multiple species (mouse, rat, rabbit, chicken, and llama), including transgenic animals providing a wide diversity for generating antibodies

Phage and Mammalian Display

Deep expertise and industry leader in both Phage display and Mammalian Display selection methods

14 antibodies in clinic

Discovered 14 antibodies that have successfully entered clinical trials for our partners over the past decade

Beyond therapeutics

Generation of antibodies beyond therapeutics, including diagnostics, anti-idiotypic, imaging, and research tools

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How We Work

2 platforms

+3 sources

mammalian display

Mammalian Display alllows the display of up to 10 million antibody (or antigen) variants on stable mammalian cell lines to enhance the discovery of antibodies. By assessing expression levels, it serves as a surrogate for developability, ensuring only clones with favourable biophysical properties progress to lead selection.

Key advantages include:

Selecting antibodies based on high expression (indicative of excellent biophysical properties);
Displaying intact IgG or versatile display formats such as bispecifics;
Accommodating diverse variant libraries;
Mimicking the final lead's expression system for successful translation to later stages.

phage display

Phage Display offers a fast and flexible approach to antibody discovery. This target-agnostic technology allows broad epitope coverage, while efficiently handling complex and highly-conserved targets, and offers a flexible selection of specific binding properties. By enabling parallel strategies, we enhance the efficiency and breadth of the discovery process, maximizing the potential for success.

2 platforms

+3 sources

Explorer™ Semi-synthetic Library

Our proprietary Explorer Library is a non-immune, semi-synthetic human antibody library with optimized developability and diversity. It features clinically-validated scaffolds and highly diverse CDRs devoid of stability liabilities.

The CDR-H3 modules are sourced entirely from healthy donors whereas all other CDRs are synthetic, modelled on human immune repertoires excluding sequence liabilities.

Shuffling CDRs boosts the potential accessible diversity and enables generation of unique binder clones, providing a fast track to clinically-ready molecules.

Non-immune Library

Non-immune llama single domain and healthy human antibody libraries present a large diversity of antibodies from natural repertoires. These libraries can be explored against any target, as a recombinant protein or over-expressed on cells, eliminating the need for animal immunization. This expedites the discovery process of specific antibodies. Human libraries preclude the necessity for humanization and permit direct formatting, while llama single domain candidates are easily humanized for clinical suitability and can serve as versatile building blocks for reformulation into bispecific/multi-specific antibody formats.

Immune Library

Animal immunizations remain popular for producing high-affinity antibodies naturally. Our track record expertise in immunizing five species (mouse, rat, rabbit, chicken, and llama) and working with transgenic or genetically modified animals, offers a flexible approach to your project requirements.

Immune-sourced antibodies can serve various purposes, including but not limited to, therapeutics, reagents, diagnostics and immunohistochemistry tools. From generating broad and cross-reactive antibodies, soluble VHH antibodies capable of targeting inaccessible epitopes, to easily humanized antibodies, we can support your clinically-fit therapeutic leads.

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